A new animal model of cerebral infarction: magnetic embolization with carbonyl iron particles

Neurosci Lett. 1995 Jul 14;194(1-2):139-41. doi: 10.1016/0304-3940(95)11738-i.

Abstract

A new animal model of cerebral infarction was developed by magnetic embolization with carbonyl iron particles. An electromagnet was placed upon the lateral portion outside the orbit of Mongolian gerbils and charged with a current intensity of 2 A, 3 V (400 G) for 10 min. By intracardiac injection of iron particles at the beginning of the electric charge, infarction was selectively produced in the cerebral cortex. Two days after the operation, microhemorrhaging was seen in the necrotic region. Multiple scattered infarctions accompanied with microhemorrhagic signs closely resembled embolic infarction encountered in the human brain.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cerebral Cortex / pathology*
  • Cerebral Infarction / pathology*
  • Disease Models, Animal*
  • Electromagnetic Phenomena*
  • Gerbillinae
  • Iron
  • Time Factors

Substances

  • Iron