Fc receptor stimulation of PI 3-kinase in NK cells is associated with protein kinase C-independent granule release and cell-mediated cytotoxicity

Ann N Y Acad Sci. 1995 Sep 7:766:209-13. doi: 10.1111/j.1749-6632.1995.tb26666.x.

Authors

J D Bonnema¹, L M Karnitz, R A Schoon, R T Abraham, P J Leibson

Affiliation

¹ Department of Immunology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA.

PMID: 7486660
DOI: 10.1111/j.1749-6632.1995.tb26666.x

No abstract available

MeSH terms

Androstadienes / pharmacology
Antibody-Dependent Cell Cytotoxicity
Cells, Cultured
Cytoplasmic Granules / immunology
Cytotoxicity, Immunologic* / drug effects
Enzyme Inhibitors / pharmacology
Humans
Indoles / pharmacology
Killer Cells, Natural / enzymology*
Killer Cells, Natural / immunology*
Killer Cells, Natural / ultrastructure
Kinetics
Maleimides / pharmacology
Phosphatidylinositol 3-Kinases
Phosphotransferases (Alcohol Group Acceptor) / metabolism*
Protein Kinase C / antagonists & inhibitors
Protein Kinase C / metabolism*
Receptors, Fc / physiology*
Signal Transduction / drug effects
Tumor Cells, Cultured
Wortmannin

Substances

Androstadienes
Enzyme Inhibitors
Indoles
Maleimides
Receptors, Fc
Phosphatidylinositol 3-Kinases
Phosphotransferases (Alcohol Group Acceptor)
Protein Kinase C
bisindolylmaleimide I
Wortmannin