Abstract
Cytotoxic chemotherapy remains the principal modality of treating advanced or unresectable sarcomas of soft tissue. Certain drugs, such as doxorubicin and ifosfamide, are able to induce clinically useful antitumor effects as single agents, and combination chemotherapy regimens have been tested based upon these results. This article summarizes the results of single agent and combination chemotherapy trials for soft tissue sarcomas.
MeSH terms
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Antineoplastic Agents / therapeutic use*
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Chemotherapy, Adjuvant
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Clinical Trials as Topic
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Combined Modality Therapy
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Cyclophosphamide / administration & dosage
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Dacarbazine / administration & dosage
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Doxorubicin / administration & dosage
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Doxorubicin / therapeutic use
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Humans
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Ifosfamide / administration & dosage
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Ifosfamide / therapeutic use
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Mesna / administration & dosage
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Randomized Controlled Trials as Topic
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Salvage Therapy
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Sarcoma / drug therapy*
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Sarcoma / radiotherapy
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Sarcoma / surgery
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Soft Tissue Neoplasms / drug therapy*
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Soft Tissue Neoplasms / radiotherapy
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Soft Tissue Neoplasms / surgery
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Treatment Outcome
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Vincristine / administration & dosage
Substances
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Antineoplastic Agents
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Vincristine
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Dacarbazine
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Doxorubicin
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Cyclophosphamide
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Mesna
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Ifosfamide
Supplementary concepts
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CYVADIC protocol
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MAID protocol