N-[(1-butyl-4-piperidinyl)methyl]-3,4dihydro-2H-[1,3]oxazino[3,2- a]indole10-carboxamide hydrochloride: the first potent and selective 5-HT4 receptor antagonist amide with oral activity

J Med Chem. 1995 Nov 24;38(24):4760-3. doi: 10.1021/jm00024a002.
No abstract available

MeSH terms

  • Administration, Oral
  • Animals
  • Dioxanes / pharmacology
  • Dogs
  • Guinea Pigs
  • Indoles / chemical synthesis
  • Indoles / pharmacology*
  • Muscle Contraction / drug effects*
  • Piperidines / chemical synthesis
  • Piperidines / pharmacology*
  • Receptors, Serotonin / drug effects*
  • Receptors, Serotonin, 5-HT4
  • Serotonin Antagonists / chemical synthesis
  • Serotonin Antagonists / pharmacology*
  • Structure-Activity Relationship
  • Sulfonamides / pharmacology

Substances

  • Dioxanes
  • Indoles
  • Piperidines
  • Receptors, Serotonin
  • SB 207266
  • Serotonin Antagonists
  • Sulfonamides
  • SB 204070A
  • Receptors, Serotonin, 5-HT4
  • GR 113808