Abstract
The complete M segment sequences of hantaviruses amplified from tissues of a patient with hantavirus pulmonary syndrome in the northeastern United States and from white-footed mice, Peromyscus leucopus, from New York were 99% identical and differed from those of Four Corners virus by 23%. The serum of this patient failed to recognize a conserved, immunodominant epitope of the Four Corners virus G1 glycoprotein. Collectively, these findings indicate that P. leucopus harbors a genetically and antigenically distinct hantavirus that causes hantavirus pulmonary syndrome.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Arvicolinae / virology
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Epitopes / analysis
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Epitopes / chemistry
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Genome, Viral*
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Hantavirus Pulmonary Syndrome / transmission*
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Hantavirus Pulmonary Syndrome / virology*
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Humans
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Molecular Sequence Data
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New England
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New York
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Orthohantavirus / classification*
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Orthohantavirus / genetics*
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Orthohantavirus / isolation & purification
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Peromyscus / virology*
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Phylogeny*
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Rats / virology
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Sequence Homology, Amino Acid
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Viral Matrix Proteins / genetics*
Substances
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Epitopes
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Viral Matrix Proteins
Associated data
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GENBANK/U36801
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GENBANK/U36802
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GENBANK/U36803
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GENBANK/U36804
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GENBANK/U36805
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GENBANK/U36806
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GENBANK/U36807
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GENBANK/U36808
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GENBANK/U36809
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GENBANK/U36810
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GENBANK/U36811
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GENBANK/U36812
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GENBANK/U36813
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GENBANK/U36814
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GENBANK/U36815
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GENBANK/U36816
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GENBANK/U36817
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GENBANK/U36818
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GENBANK/U36819
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GENBANK/U36820
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GENBANK/U36821