Down-regulation of mitochondrial mRNAs in the mdx mouse model for Duchenne muscular dystrophy

FEBS Lett. 1995 Nov 20;375(3):268-72. doi: 10.1016/0014-5793(95)01225-4.

Abstract

In our search for genes up- or down-regulated genes in the mdx mouse model for Duchenne muscular dystrophy, we isolated a down-regulated mitochondrial DNA clone. In addition to this clone, all protein-coding mitochondrial genes tested had tissue-specific and age independent down-regulated expression. This implied mechanisms at the RNA level since no change in the mitochondrial DNA contents were detected. Cytochrome c oxidase activity showed the same range of down-regulated expression. These data provide a molecular basis for energetic metabolism modifications in mdx mice.

Publication types

  • Comparative Study

MeSH terms

  • Aging / metabolism*
  • Animals
  • Base Sequence
  • Blotting, Northern
  • DNA Primers
  • Electron Transport Complex IV / biosynthesis
  • Electron Transport Complex IV / metabolism*
  • Gene Expression Regulation
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred mdx
  • Mitochondria, Muscle / metabolism*
  • Molecular Sequence Data
  • Muscle Development
  • Muscle, Skeletal / growth & development
  • Muscle, Skeletal / metabolism
  • Muscular Dystrophy, Animal / genetics*
  • Muscular Dystrophy, Animal / metabolism*
  • Organ Specificity
  • Polymerase Chain Reaction
  • RNA / biosynthesis*
  • RNA, Messenger / biosynthesis*
  • RNA, Mitochondrial
  • Reference Values

Substances

  • DNA Primers
  • RNA, Messenger
  • RNA, Mitochondrial
  • RNA
  • Electron Transport Complex IV