Abstract
The effect of heparin on generation and activity of NK cells in vitro were studied. Heparin decreased NK cytotoxicity when present in the assay. In contrast, the agent increased generation of NK cytotoxicity and showed synergistic action with recombinant IL2.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adjuvants, Immunologic / pharmacology*
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Cytotoxicity, Immunologic / drug effects
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Heparin / pharmacology*
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Humans
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Immunotherapy, Adoptive
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Interleukin-2 / pharmacology
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Killer Cells, Natural / drug effects*
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Killer Cells, Natural / immunology*
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Leukemia / therapy
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Tumor Cells, Cultured
Substances
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Adjuvants, Immunologic
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Interleukin-2
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Heparin