Abstract
A course injection of Rhodiola rosea extract for eight days was reported to increase the resistance of experimental animals to adrenalin- or CaCl2-induced arrhythmias. Preliminary injection of naloxone in a dose of 0.5 mg/kg eliminated the antiarrhythmic effect of Rhodiola. Indomethacin had no effect the antiarrhythmic action of Rhodiola. The antiarrhythmic effect of Rhodiola course injections was assumed to be associated with the induction of opioid peptides biosynthesis.
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Animals
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Anti-Arrhythmia Agents / pharmacology
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Anti-Arrhythmia Agents / therapeutic use*
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Calcium Chloride
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Cardiac Complexes, Premature / chemically induced
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Cardiac Complexes, Premature / drug therapy
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Disease Models, Animal
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Drug Evaluation, Preclinical
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Epinephrine
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Indomethacin / pharmacology
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Male
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Naloxone / pharmacology
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Plant Extracts / pharmacology
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Plant Extracts / therapeutic use*
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Rats
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Rats, Wistar
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Ventricular Fibrillation / chemically induced
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Ventricular Fibrillation / drug therapy
Substances
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Anti-Arrhythmia Agents
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Plant Extracts
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Naloxone
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Calcium Chloride
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Indomethacin
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Epinephrine