Inducible nitric oxide synthase activity in hepatocytes is dependent on the coinduction of tetrahydrobiopterin synthesis

Adv Exp Med Biol. 1993:338:305-8. doi: 10.1007/978-1-4615-2960-6_63.
No abstract available

MeSH terms

  • Amino Acid Oxidoreductases / biosynthesis*
  • Animals
  • Arginine / analogs & derivatives
  • Arginine / pharmacology
  • Biopterins / analogs & derivatives*
  • Biopterins / biosynthesis
  • Cells, Cultured
  • Cytokines / pharmacology
  • Enzyme Induction
  • GTP Cyclohydrolase / biosynthesis*
  • Gene Expression
  • Hypoxanthines / pharmacology
  • Lipopolysaccharides / pharmacology
  • Liver / drug effects
  • Liver / enzymology
  • Liver / metabolism*
  • Methotrexate / pharmacology
  • Nitric Oxide / metabolism
  • Nitric Oxide Synthase
  • RNA, Messenger / metabolism
  • Rats
  • omega-N-Methylarginine

Substances

  • Cytokines
  • Hypoxanthines
  • Lipopolysaccharides
  • RNA, Messenger
  • Biopterins
  • omega-N-Methylarginine
  • Nitric Oxide
  • Arginine
  • Nitric Oxide Synthase
  • Amino Acid Oxidoreductases
  • GTP Cyclohydrolase
  • 2,4-diaminohypoxanthine
  • sapropterin
  • Methotrexate