Calcineurin is a key signaling enzyme in T lymphocyte activation and the target of the immunosuppressive drugs cyclosporin A and FK506

Ann N Y Acad Sci. 1993 Nov 30:696:20-30. doi: 10.1111/j.1749-6632.1993.tb17138.x.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Calcineurin
  • Calmodulin-Binding Proteins / genetics
  • Calmodulin-Binding Proteins / physiology*
  • Cell Line
  • Cyclosporine / pharmacology*
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / physiology
  • Humans
  • Lymphocyte Activation / drug effects*
  • NFATC Transcription Factors
  • Nuclear Proteins*
  • Phosphoprotein Phosphatases / genetics
  • Phosphoprotein Phosphatases / physiology*
  • T-Lymphocytes / drug effects*
  • T-Lymphocytes / immunology
  • Tacrolimus / pharmacology*
  • Tetradecanoylphorbol Acetate / pharmacology
  • Transcription Factors / genetics
  • Transcription Factors / physiology
  • Transcription, Genetic

Substances

  • Calmodulin-Binding Proteins
  • DNA-Binding Proteins
  • NFATC Transcription Factors
  • Nuclear Proteins
  • Transcription Factors
  • Cyclosporine
  • Calcineurin
  • Phosphoprotein Phosphatases
  • Tetradecanoylphorbol Acetate
  • Tacrolimus