Abstract
We described synthesis of 1-aryl-3 and 5-substituted 2-pyrrolidinones (2a--5a and 3b--4b). Pharmacological studies revealed that compounds 3b, 4a and 4b have analgetic and antiinflammatory properties. None of the compounds posesses neuroleptic or anticonvulsant properties.
MeSH terms
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Analgesics
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Animals
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Anti-Inflammatory Agents
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Chemical Phenomena
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Chemistry
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Lethal Dose 50
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Male
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Mice
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Motor Activity / drug effects
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Pyrrolidinones / chemical synthesis*
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Pyrrolidinones / pharmacology
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Pyrrolidinones / toxicity
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Rats
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Reaction Time / drug effects
Substances
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Analgesics
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Anti-Inflammatory Agents
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Pyrrolidinones