Abstract
The effect of various preparations of human interferon (HuIFN) upon human immunodeficiency virus (HIV-1) replication in cell lines and primary cultures of peripheral blood lymphocytes (PBL) was investigated. Natural interferon alpha (nHuIFN-alpha) exhibited a much higher inhibitory effect upon HIV-1 replication than did recombinant HuIFN-alpha (rHuIFN-alpha).
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Cell Line
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HIV-1 / drug effects*
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HIV-1 / physiology
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Humans
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Interferon-alpha / pharmacology
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Interferon-beta / pharmacology
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Interferon-gamma / pharmacology
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Interferons / pharmacology*
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Lymphocytes / microbiology
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Virus Replication / drug effects*
Substances
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Interferon-alpha
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Interferon-beta
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Interferon-gamma
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Interferons