Abstract
Calcium influx via action potentials in differentiating nerve and muscle is regulated principally by the expression of potassium currents. Transient elevations of intracellular calcium in spontaneously active cells are necessary for normal neuronal development. The mechanisms that connect calcium elevations to long term developmental change are likely to be utilized in the mature nervous system.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Action Potentials
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Animals
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Animals, Newborn / growth & development
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Calcium / metabolism*
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Cell Differentiation
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Electrophysiology
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Embryonic and Fetal Development
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Growth Substances / physiology
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Ion Channel Gating
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Ion Channels / metabolism
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Ion Channels / physiology
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Neurons / metabolism*
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Neurons / physiology*
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Potassium / physiology
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Time Factors
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Transcription, Genetic
Substances
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Growth Substances
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Ion Channels
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Potassium
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Calcium