Abstract
The role of costimulation in Ag-induced responses of naive and differentiated IL-2 and IL-4-producing CD4+ T cells has been examined using cells from mice expressing a transgenic TCR specific for cytochrome c (81-104) + I-Ek. IL-2 secretion by naive and pre-activated T cells is dependent on costimulation, because it is not induced with chemically fixed APCs and is significantly inhibited by the B7 antagonist, CTLA4-Ig. In contrast, IL-4 secretion by in vitro differentiated Th2-like cells is relatively independent of costimulators. Thus, the requirement for costimulation is related more to lymphokine secretion profiles than to the previous activation status of CD4+ T lymphocytes.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Abatacept
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Animals
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Antigen-Presenting Cells / physiology
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Antigens, CD
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Antigens, Differentiation / physiology
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B7-1 Antigen / physiology
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CD4-Positive T-Lymphocytes / metabolism*
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CTLA-4 Antigen
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Immunoconjugates*
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Interleukin-12
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Interleukin-2 / metabolism*
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Interleukin-4 / metabolism*
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Interleukin-4 / pharmacology
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Interleukins / pharmacology
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Lymphocyte Activation*
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Mice
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Mice, Transgenic
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Receptors, Antigen, T-Cell / genetics*
Substances
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Antigens, CD
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Antigens, Differentiation
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B7-1 Antigen
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CTLA-4 Antigen
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Ctla4 protein, mouse
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Immunoconjugates
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Interleukin-2
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Interleukins
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Receptors, Antigen, T-Cell
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Interleukin-12
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Interleukin-4
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Abatacept