Motor cortex inhibition in patients with ataxia

Electroencephalogr Clin Neurophysiol. 1994 Jun;93(3):225-9. doi: 10.1016/0168-5597(94)90044-2.

Abstract

We studied the effects of a subthreshold magnetic stimulus over the motor cortex and an electrical stimulus over the cerebellum on EMG responses produced by a suprathreshold magnetic stimulus over the motor cortex. In normal subjects, both subthreshold conditioning stimuli and cerebellar stimuli could suppress responses to suprathreshold magnetic test stimuli when given at appropriate timings: "cortico-cortical" and "cerebellar" inhibition, respectively. In all patients with degenerative ataxias and patients with a lesion in the cerebellar thalamus, the "cortico-cortical" inhibition was normal and the "cerebellar" inhibition was absent. We conclude that cerebellar systems make no or little contribution to the above-mentioned "cortico-cortical" inhibition.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Analysis of Variance
  • Ataxia / physiopathology*
  • Electromyography
  • Humans
  • Magnetics
  • Middle Aged
  • Motor Cortex / physiopathology*
  • Neural Inhibition
  • Time Factors