Abstract
Poly(benzyl L-glutamate) (PBLG) microcapsules, prepared by a solvent evaporation technique for intravenous injection, are evaluated for their potential use in diagnostic computed tomographic enhancement of liver images. The smaller microcapsules, < 3 microns, loaded with a radiopaque contrast material, ethyl iopanoate (IOPAE), produced prolonged opacification of the liver when delivered intravenously. In vivo tissue distribution studies of PBLG-131I-IOPAE (5 microCi/rat, iv) showed that liver had the highest uptake (percent of injected dose/g of tissue) among other organs 24 h postinjection. An in vitro estrogen receptor assay in pig uteri indicated that PBLG conjugated with estrone did not interfere with estrogen receptor affinity, suggesting the estrogen therapy potential of PBLG-estrone.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Capsules
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Contrast Media / chemistry*
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Contrast Media / pharmacokinetics
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Drug Carriers
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Enzymes / blood
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Estrone / administration & dosage
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Estrone / analogs & derivatives
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Estrone / pharmacokinetics
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Female
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Iopanoic Acid / administration & dosage
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Iopanoic Acid / analogs & derivatives
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Iopanoic Acid / pharmacokinetics
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Kidney / diagnostic imaging
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Liver / diagnostic imaging
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Particle Size
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Polyglutamic Acid / analogs & derivatives*
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Polyglutamic Acid / chemistry
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Polyglutamic Acid / pharmacokinetics
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Rabbits
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Rats
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Receptors, Estrogen / metabolism
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Swine
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Tissue Distribution
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Tomography, X-Ray Computed
Substances
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Capsules
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Contrast Media
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Drug Carriers
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Enzymes
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Receptors, Estrogen
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ethyl iopanoate
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3-aminoethylestrone
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poly-gamma-benzyl-L-glutamate
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Polyglutamic Acid
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Estrone
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Iopanoic Acid