Abstract
The reversal of endothelin-1 induced cerebral vasospasm with Iloprost was studied in the rabbit. Vasospasm in the basilar artery was evaluated by angiography; cerebral ischaemia by 'red-neurone-count' on light microscopy and morphological changes by electron microscopy. A potent antagonistic effect of Iloprost against ET-1 was observed in each of the parameters measured.
MeSH terms
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Animals
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Basilar Artery / pathology
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Basilar Artery / ultrastructure
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Brain / pathology
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Brain / ultrastructure
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Cerebral Angiography
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Endothelins / administration & dosage
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Endothelins / antagonists & inhibitors*
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Endothelins / pharmacology
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Female
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Iloprost / administration & dosage
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Iloprost / pharmacology*
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Injections, Intra-Arterial
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Ischemic Attack, Transient / chemically induced
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Ischemic Attack, Transient / pathology
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Ischemic Attack, Transient / prevention & control*
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Male
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Neurons / drug effects
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Neurons / ultrastructure
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Rabbits
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Subarachnoid Hemorrhage / pathology