Serotonin receptors and therapeutics

Cell Mol Biol (Noisy-le-grand). 1994 May;40(3):327-36.

Abstract

Since its discovery, serotonin (5-hydroxytryptamine = 5-HT) has become a major player on the neurotransmitter "stage". Multiple receptor subtypes for 5-HT have been identified and classified, and a vast pharmacology of 5-HT has emerged. In particular, 5-HT has been shown to exert marked effects on the cardiovascular system, central nervous system (CNS) and gastrointestinal (GI) tract, and important ligands have been developed that mimic or block its action selectively. Furthermore, drugs that release 5-HT, and others that prevent its uptake, have been developed. This brief review focuses on the pharmacology of 5-HT agonists and antagonists that exhibit, at least partly, clinical relevance.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Anxiety Agents / therapeutic use
  • Antidepressive Agents / therapeutic use
  • Antiemetics / therapeutic use
  • Cricetinae
  • Cyclic AMP / physiology
  • Dogs
  • Drosophila
  • Humans
  • Ion Channels / drug effects
  • Mental Disorders / drug therapy*
  • Mental Disorders / physiopathology
  • Mice
  • Migraine Disorders / drug therapy
  • Molecular Structure
  • Rats
  • Receptors, Serotonin / classification
  • Receptors, Serotonin / drug effects*
  • Receptors, Serotonin / physiology
  • Selective Serotonin Reuptake Inhibitors / chemistry
  • Selective Serotonin Reuptake Inhibitors / classification
  • Selective Serotonin Reuptake Inhibitors / pharmacology
  • Selective Serotonin Reuptake Inhibitors / therapeutic use*
  • Serotonin / physiology*
  • Serotonin Antagonists / chemistry
  • Serotonin Antagonists / classification
  • Serotonin Antagonists / pharmacology
  • Serotonin Antagonists / therapeutic use*
  • Serotonin Receptor Agonists / chemistry
  • Serotonin Receptor Agonists / classification
  • Serotonin Receptor Agonists / pharmacology
  • Serotonin Receptor Agonists / therapeutic use*
  • Signal Transduction
  • Structure-Activity Relationship
  • Vomiting / drug therapy

Substances

  • Anti-Anxiety Agents
  • Antidepressive Agents
  • Antiemetics
  • Ion Channels
  • Receptors, Serotonin
  • Serotonin Antagonists
  • Serotonin Receptor Agonists
  • Serotonin Uptake Inhibitors
  • Serotonin
  • Cyclic AMP