We have made a retrospective study on 621 HBsAg negative plasma donors, 354 HBsAg negative non-blood donors, 124 HBsAg positive plasma donors and 124 HBsAg positive non-blood donors. Results showed that the respective positive rates of anti-HCV were 84.2%, 0.85%, 41.9% and 1.6%, and that the respective prevalence rates of viral hepatitis were 34.9%, 1.98%, 18.5% and 4.8%, respectively. These figures suggest that HCV infection and the epidemic of hepatitis C mostly occur among the plasma donors.