Noninvasive assessment of regional arteriolar and arterial dilating properties of lisinopril in healthy volunteers

J Cardiovasc Pharmacol. 1994 Sep;24(3):500-8. doi: 10.1097/00005344-199409000-00020.

Abstract

The effects of single oral doses of lisinopril (5 and 20 mg) on systemic and regional hemodynamics were investigated noninvasively in a placebo-controlled, randomized, double-blind, cross-over study of 6 healthy male volunteers. Lisinopril induced a dose-dependent (significant after 20 mg) and long-lasting (< or = 8 h) decrease in mean arterial pressure (MAP, approximately 11% after 20 mg) that was related to a decrease in total peripheral resistance (TPR), because simultaneously heart rate (HR) and cardiac output (CO) were unchanged. Brachial artery flow (+42 and +47% after 5 and 20 mg, respectively) and diameter (+8 and +9%) increased significantly, whereas brachial vascular resistance (-31 and -38%) decreased significantly from 2 to 8 h after drug intake. Common carotid artery flow (+20 and +24%) also increased significantly, whereas corresponding resistance (-18 and -26%) decreased significantly during the same period. Finally, CO was significantly redistributed toward the brachial and, to a lesser extent, the carotid vascular beds after both doses of lisinopril. We conclude that in healthy subjects lisinopril, at non- or slightly hypotensive doses, dilates both arterioles and large arteries and that this vasodilation is not homogeneous, affecting preferentially the brachial rather than the carotid vascular bed.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Adult
  • Analysis of Variance
  • Arteries / drug effects*
  • Arteries / physiology
  • Arterioles / drug effects*
  • Arterioles / physiology
  • Blood Pressure / drug effects
  • Brachial Artery / drug effects
  • Brachial Artery / metabolism
  • Brachial Artery / physiology
  • Cardiac Output / drug effects
  • Carotid Arteries / drug effects
  • Carotid Arteries / metabolism
  • Carotid Arteries / physiology
  • Cross-Over Studies
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Drug Evaluation
  • Heart Rate / drug effects
  • Hemodynamics / drug effects*
  • Humans
  • Laser-Doppler Flowmetry
  • Lisinopril / administration & dosage
  • Lisinopril / pharmacokinetics
  • Lisinopril / pharmacology*
  • Male
  • Regional Blood Flow / drug effects
  • Vascular Resistance / drug effects
  • Vasodilation / drug effects*

Substances

  • Lisinopril