Abstract
During their progression, epithelial tumors induce a stromal reaction essential for their development and for metastasis. In situ hybridization studies have revealed that the protooncogene c-ets1 is expressed in endothelial cells at the beginning tumor angiogenesis, and in stromal fibroblasts surrounding invasive tumors. C-ets1 encodes a transcription factor that may activate the transcription of genes encoding collagenase 1, stromelysin 1 and urokinase plasminogen activator, proteases involved in extracellular matrix degradation. A working hypothesis is that c-Ets1 takes part in regulating invasive processes by controlling the transcription of these genes. Experimental evidences that may confirm this hypothesis will be discussed.
MeSH terms
-
Animals
-
Base Sequence
-
Carcinoma / genetics*
-
Collagenases / genetics
-
DNA, Neoplasm / genetics*
-
Gene Expression Regulation, Neoplastic / genetics*
-
Humans
-
Matrix Metalloproteinase 3
-
Metalloendopeptidases / genetics
-
Molecular Sequence Data
-
Neoplasm Invasiveness / genetics*
-
Neoplasm Proteins / genetics
-
Neovascularization, Pathologic / genetics*
-
Poultry
-
Proto-Oncogene Protein c-ets-1
-
Proto-Oncogene Proteins / genetics*
-
Proto-Oncogene Proteins c-ets
-
Transcription Factors / genetics*
-
Urokinase-Type Plasminogen Activator / genetics
Substances
-
DNA, Neoplasm
-
ETS1 protein, human
-
Neoplasm Proteins
-
Proto-Oncogene Protein c-ets-1
-
Proto-Oncogene Proteins
-
Proto-Oncogene Proteins c-ets
-
Transcription Factors
-
Urokinase-Type Plasminogen Activator
-
Collagenases
-
Metalloendopeptidases
-
Matrix Metalloproteinase 3