Abstract
Spontaneous secretion of interleukin 1 (IL-1) alpha, IL-1 beta and tumour necrosis factor-alpha (TNF-alpha) from acute myelogenous leukaemia (AML) blasts showed significant correlation, and detectable levels of all cytokines were seen for a majority of patients. IL-3 and granulocyte/macrophage colony-stimulating factor increased secretion of IL-1 alpha, IL-1 beta and TNF-alpha for a majority of AML patients, whereas IL-4 decreased cytokine secretion. The effect of IL-6 and stem cell factor on cytokine secretion varied between different patients. A wide variation in IL-1 alpha, IL-1 beta and TNF-alpha secretion between different patients was seen both for spontaneous secretion and in the presence of all cytokines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Cell Adhesion Molecules / pharmacology
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Cytokines / pharmacology*
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Female
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Granulocyte Colony-Stimulating Factor / pharmacology
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Granulocyte-Macrophage Colony-Stimulating Factor / pharmacology
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Hematopoietic Cell Growth Factors / pharmacology
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Humans
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Interleukin-1 / metabolism*
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Interleukin-3 / pharmacology
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Interleukin-4 / pharmacology
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Interleukin-6 / pharmacology
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Leukemia, Myeloid, Acute / immunology
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Leukemia, Myeloid, Acute / pathology
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Leukemia, Myeloid, Acute / physiopathology*
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Lymphocyte Activation / drug effects
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Lymphocyte Activation / physiology
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Male
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Middle Aged
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Stem Cell Factor
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Tumor Cells, Cultured / drug effects
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Tumor Necrosis Factor-alpha / metabolism*
Substances
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Cell Adhesion Molecules
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Cytokines
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Hematopoietic Cell Growth Factors
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Interleukin-1
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Interleukin-3
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Interleukin-6
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Stem Cell Factor
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Tumor Necrosis Factor-alpha
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Granulocyte Colony-Stimulating Factor
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Interleukin-4
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Granulocyte-Macrophage Colony-Stimulating Factor