Dendritic development in normal lumbar motoneurons and following neonatal nerve crush in the rat

Dev Neurosci. 1994;16(1-2):17-24. doi: 10.1159/000112082.

Abstract

Motoneurons from the rat were retrogradely labelled with cholera toxin-horseradish peroxidase at intervals during normal postnatal development and following nerve crush at birth. Normal cells displayed a relatively steady increase in total visible dendritic density which was largely confined to the dorsomedial direction. After nerve crush at birth, dorsomedially orientated dendrites failed to achieve normal density, resulting in a significantly smaller dendritic tree by adulthood. There was also a transient, abnormal extension of dendrites in the medioventral direction which had regressed to normal levels by maturity. The predominance of changes in the dorsally directed region of the dendritic tree suggests that dendritic development of motoneurons is influenced by synaptic inputs in the dorsal horn.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / physiology*
  • Animals
  • Animals, Newborn
  • Axonal Transport
  • Dendrites / physiology*
  • Dendrites / ultrastructure
  • Motor Neurons / cytology
  • Motor Neurons / physiology*
  • Nerve Crush
  • Peroneal Nerve / physiology*
  • Rats
  • Rats, Wistar
  • Reference Values
  • Spinal Cord / cytology
  • Spinal Cord / physiology*