Abstract
In this open randomized study, we evaluated the efficacy of Tranilast, one of the anti-inflammatory drugs, on otitis media with effusion in children. Sixty-two patients (103 ears) were divided into two groups: Group A was given Tranilast and local treatment (nasal and tubal); Group B only received local treatment (control for Group A). The overall improvement rating assessed as "moderately improved or above" for Group A was 63.6%, Group B 47.9%. There was a significant improvement in Group A as compared to Group B (p < 0.05). In subjects who suffered from otitis media with effusion for over 2 months. Group A exhibited 50.0% of efficacy while Group B only 15.4% (p < 0.05).
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
MeSH terms
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Acoustic Impedance Tests
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Adolescent
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Anti-Inflammatory Agents
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
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Audiometry
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Child
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Child, Preschool
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Ear, Middle / physiopathology
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Female
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Humans
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Infant
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Infant, Newborn
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Male
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Otitis Media with Effusion / drug therapy*
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Otitis Media with Effusion / physiopathology
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Treatment Outcome
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Tympanic Membrane / drug effects
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ortho-Aminobenzoates / pharmacology
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ortho-Aminobenzoates / therapeutic use*
Substances
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Anti-Inflammatory Agents
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Anti-Inflammatory Agents, Non-Steroidal
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ortho-Aminobenzoates
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tranilast