E-selectin expression in salivary endothelial cells and sera from patients with systemic sclerosis. Role of resident mast cell-derived tumor necrosis factor alpha

M Hebbar; P Lassalle; A Janin; D Vanhée; S Bisiau; P Y Hatron; A B Tonnel; B Gosselin

doi:10.1002/art.1780380318

E-selectin expression in salivary endothelial cells and sera from patients with systemic sclerosis. Role of resident mast cell-derived tumor necrosis factor alpha

Arthritis Rheum. 1995 Mar;38(3):406-12. doi: 10.1002/art.1780380318.

Authors

M Hebbar¹, P Lassalle, A Janin, D Vanhée, S Bisiau, P Y Hatron, A B Tonnel, B Gosselin

Affiliation

¹ Unité INSERM 416, Institut Pasteur, Lille, France.

PMID: 7533494
DOI: 10.1002/art.1780380318

Abstract

Objective: To assess endothelial cell activation in patients with systemic sclerosis (SSc).

Methods: Concomitant study of salivary gland biopsy tissues and sera for expression of E-selectin and its potent activator tumor necrosis factor alpha (TNF alpha), using immunostaining and enzyme-linked immunosorbent essay.

Results: E-selectin was overexpressed in SSc patients, but not in controls. TNF alpha was detected in mast cells.

Conclusion: Mast cell-derived TNF alpha may contribute to endothelial cell activation in SSc.

Publication types

Comparative Study

MeSH terms

Adolescent
Adult
Aged
Biopsy
Cell Adhesion / physiology
Cell Adhesion Molecules / analysis*
Cell Adhesion Molecules / blood
E-Selectin
Endothelium / chemistry
Female
Humans
Male
Mast Cells / chemistry
Middle Aged
Salivary Glands, Minor / chemistry*
Salivary Glands, Minor / pathology
Scleroderma, Systemic / physiopathology*
Sjogren's Syndrome / physiopathology
Tumor Necrosis Factor-alpha / analysis

Substances

Cell Adhesion Molecules
E-Selectin
Tumor Necrosis Factor-alpha