Novel fluoroprostacyclin analogs with modified cycloalkylenyl chains. Highly potent and orally active anti-anginal agents

Chem Pharm Bull (Tokyo). 1995 Feb;43(2):353-5. doi: 10.1248/cpb.43.353.

Abstract

Novel fluoroprostacyclin analogs (1a-f) have been synthesized and pharmacologically evaluated. Compounds 1a-c given intravenously or orally showed potent and long-lasting anti-anginal activities in an animal model.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Administration, Oral
  • Angina Pectoris / drug therapy*
  • Animals
  • Blood Pressure / drug effects*
  • Dose-Response Relationship, Drug
  • Drug Evaluation
  • Electrocardiography / drug effects
  • Epoprostenol / administration & dosage
  • Epoprostenol / analogs & derivatives*
  • Epoprostenol / pharmacology
  • Epoprostenol / therapeutic use
  • Fluorine / chemistry
  • Guinea Pigs
  • Heart / drug effects*
  • Iloprost / administration & dosage
  • Iloprost / pharmacology
  • Injections, Intravenous
  • Platelet Aggregation / drug effects*
  • Rats
  • Stereoisomerism
  • Structure-Activity Relationship
  • Vasopressins / toxicity

Substances

  • Vasopressins
  • Fluorine
  • Epoprostenol
  • Iloprost