Abstract
Serum soluble c-kit concentrations were measured in 11 patients with or without acute graft-versus-host disease (GVHD) after allogeneic bone marrow transplantation. The serum soluble c-kit levels in the patients with moderate to severe acute GVHD (grade II-IV) were significantly lower than those in the patients with no or mild acute GVHD (grade 0-I) following the onset. The data from this study indicate that measurement of serum soluble c-kit concentration is a useful indicator of severe acute GVHD.
Publication types
-
Case Reports
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adolescent
-
Adult
-
Bone Marrow Transplantation*
-
Female
-
Graft vs Host Disease / blood
-
Graft vs Host Disease / diagnosis*
-
Humans
-
Male
-
Proto-Oncogene Proteins / metabolism*
-
Proto-Oncogene Proteins c-kit
-
Receptor Protein-Tyrosine Kinases / metabolism*
-
Receptors, Colony-Stimulating Factor / metabolism*
-
Transplantation, Homologous
Substances
-
Proto-Oncogene Proteins
-
Receptors, Colony-Stimulating Factor
-
Proto-Oncogene Proteins c-kit
-
Receptor Protein-Tyrosine Kinases