Abstract
Two bioactive novel triterpene glycosides named hovenidulciosides A1 and A2 have been isolated from a Chinese natural medicine, Hoveniae Semen Seu Fructus, the seeds and fruit of Hovenia dulcis Thunb. (Rhamnaceae). The absolute stereostructures of hovenidulciosides A1 and A2 with a migrated 16,17-seco-dammarane skeleton have been determined on the basis of chemical and physicochemical evidence which included the X-ray crystallographic analysis of the p-bromobenzoate of their common aglycone, hovenidulcigenin A. Hovenidulciosides A1 and A2 exhibited inhibitory activity on the histamine release from rat mast cells induced by compound 48/80 or calcium ionophore A-23187.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Calcimycin / antagonists & inhibitors
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Calcimycin / pharmacology
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Chemical Phenomena
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Chemistry, Physical
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Drugs, Chinese Herbal / chemistry*
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Fruit / chemistry
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Histamine Release / drug effects
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Magnetic Resonance Spectroscopy
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Mast Cells / drug effects
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Mast Cells / metabolism
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Molecular Structure
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Plants, Medicinal / chemistry*
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Rats
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Saponins / chemistry*
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Saponins / isolation & purification
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Saponins / pharmacology*
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Seeds / chemistry
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Stereoisomerism
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Triterpenes*
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p-Methoxy-N-methylphenethylamine / pharmacology
Substances
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Drugs, Chinese Herbal
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Saponins
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Triterpenes
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hovenidulcioside A1
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hovenidulcioside A2
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Calcimycin
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p-Methoxy-N-methylphenethylamine