Suppression of experimental antigen-induced arthritis in transgenic mice producing human alpha-fetoprotein

Biochem Biophys Res Commun. 1995 Aug 4;213(1):362-6. doi: 10.1006/bbrc.1995.2138.

Abstract

Experimental arthritis was induced in the knee joint of transgenic mice expressing human alpha-fetoprotein by immunization with methylated bovine serum albumin in Freund's complete adjuvant. In the control experiment with normal C57BL/6 mice, definite arthritis was observed in 55.6% (5/9) of the mice, but in only 21.1% (4/19) of the transgenic mice. This result suggested that human alpha-fetoprotein functioned as an immunosuppressant to ameliorate the development of the immune disease.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Arthritis, Experimental / immunology
  • Arthritis, Experimental / pathology
  • Arthritis, Experimental / prevention & control*
  • Freund's Adjuvant
  • Humans
  • Hypertrophy
  • Immunosuppressive Agents*
  • Inflammation
  • Joints / pathology
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Serum Albumin, Bovine / immunology
  • Synovial Membrane / pathology
  • alpha-Fetoproteins / biosynthesis*

Substances

  • Immunosuppressive Agents
  • alpha-Fetoproteins
  • methylated bovine serum albumin
  • Serum Albumin, Bovine
  • Freund's Adjuvant