Inhibition of nitric oxide synthase dramatically potentiates seizures induced by kainic acid and pilocarpine in rats

R Maggio; F Fumagalli; E Donati; P Barbier; G Racagni; G U Corsini; M Riva

doi:10.1016/0006-8993(95)00217-e

Inhibition of nitric oxide synthase dramatically potentiates seizures induced by kainic acid and pilocarpine in rats

Brain Res. 1995 May 8;679(1):184-7. doi: 10.1016/0006-8993(95)00217-e.

Authors

R Maggio¹, F Fumagalli, E Donati, P Barbier, G Racagni, G U Corsini, M Riva

Affiliation

¹ Institute of Pharmacology, School of Medicine, University of Pisa, Italy.

PMID: 7544223
DOI: 10.1016/0006-8993(95)00217-e

Abstract

We investigated whether the severity of convulsions evoked by kainic acid and pilocarpine is modified in nitric oxide synthase inhibitor-treated rats. We found that chronic treatment (4 days) with NW-nitro-L-arginine greatly potentiates seizures induced by both convulsants suggesting a potential role for nitric oxide in mechanisms regulating seizure induction and propagation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Oxidoreductases / antagonists & inhibitors*
Animals
Arginine / analogs & derivatives*
Arginine / pharmacology
Drug Synergism
Injections, Intraperitoneal
Kainic Acid / pharmacology*
Male
Nitric Oxide Synthase
Nitroarginine
Pilocarpine / pharmacology*
Rats
Rats, Sprague-Dawley
Seizures / chemically induced*

Substances

Pilocarpine
Nitroarginine
Arginine
Nitric Oxide Synthase
Amino Acid Oxidoreductases
Kainic Acid