This study evaluated the prevalence of genetic dental defects of children within different levels of inbreeding in Borj Salhi, Tunisia. One hundred and twenty one children six to nineteen years old were studied. Results were compared to Tunisian Pediatric Dentistry Society report. The findings showed high prevalence of dental structure anomalies (16%) and malocclusions (28%). It was concluded that genetic factors are responsible for a statistically significant portion of the dental anomalies.