Barrier membranes composed of resorbable collagen have demonstrated potential for use in guided tissue regeneration (GTR) procedures for repair and regeneration of periodontal defects. This article reviews the rationale for use of a collagen membrane in GTR therapy and related clinical procedures. Characteristics of the material are outlined, and indications and contraindications for utilization are discussed. Two cases are presented to demonstrate details of these principles and techniques. The learning objective of this article is to familiarize the reader with a new absorbable collagen membrane and its application in the periodontal area.