Pain relief after inguinal hernia repair: a randomized double-blind study

Br J Surg. 1995 Sep;82(9):1245-7. doi: 10.1002/bjs.1800820929.

Abstract

A randomized double-blind study was undertaken using 0.5 per cent bupivacaine ilioinguinal field block and oral papaveretum-aspirin tablets to assess pain relief after hernia surgery. A consecutive series of 200 men undergoing repair of a unilateral inguinal hernia underwent random allocation into one of the four groups to receive: bupivacaine and papaveretum-aspirin (group 1), bupivacaine and oral placebo (group 2), saline and papaveretum-aspirin (group 3), or saline and oral placebo (group 4). Patients were prescribed postoperative opiates to be given on demand. Pain levels and mobility were assessed at 6 and 24 h after operation. Patients in group 1 reported significantly less pain, required less additional opiates and had better mobility than those in group 4 (pain score P < 0.001 at 6 h and P = 0.002 at 24 h) and group 3 (P = 0.002 for pain and mobility scores at 6 h). Bupivacaine alone provided good immediate postoperative pain relief (P = 0.002 group 2 versus group 4 at 6 h). The combination of bupivacaine and papaveretum-aspirin provided the best results and is suitable for day-case postoperative analgesia.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Adolescent
  • Adult
  • Aged
  • Ambulatory Surgical Procedures
  • Analgesics / administration & dosage
  • Aspirin / administration & dosage
  • Bupivacaine / administration & dosage
  • Double-Blind Method
  • Drug Combinations
  • Hernia, Inguinal / surgery*
  • Humans
  • Male
  • Middle Aged
  • Nerve Block
  • Opium / adverse effects
  • Pain Measurement
  • Pain, Postoperative / prevention & control*
  • Tablets

Substances

  • Analgesics
  • Drug Combinations
  • Tablets
  • Opium
  • Aspirin
  • Bupivacaine