Abstract
The spatial distribution of Dlx-2 protein during murine tooth development has been investigated using immunohistochemistry with Dlx-2 antibodies. In common with several other homeobox genes expressed in toothgerms, Dlx-2 shows a multiphasic distribution in both epithelially and mesenchymally derived structures. This localization shows a number of similarities with the expression of Msx-2 and suggests a role for Dlx-2 in tooth initiation and tissue patterning.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Ameloblasts / metabolism
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Ameloblasts / ultrastructure
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Animals
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Antibodies
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Cytoskeletal Proteins
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DNA-Binding Proteins / genetics*
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Dental Papilla / metabolism
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Dental Papilla / ultrastructure
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Ectoderm / metabolism
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Ectoderm / ultrastructure
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Epithelium / metabolism
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Epithelium / ultrastructure
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Gene Expression Regulation, Developmental
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Genes, Homeobox / genetics*
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Homeodomain Proteins*
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Immunohistochemistry
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Mesoderm / metabolism
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Mesoderm / ultrastructure
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Mice
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Mice, Inbred BALB C
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Odontogenesis / genetics*
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Proteins / genetics*
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RNA-Binding Proteins
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Tooth Germ / metabolism
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Tooth Germ / ultrastructure
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Transcription Factors
Substances
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Antibodies
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Cytoskeletal Proteins
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DNA-Binding Proteins
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Distal-less homeobox proteins
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Homeodomain Proteins
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MSX2 protein
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Proteins
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RNA-Binding Proteins
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Tes protein, mouse
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Transcription Factors