Relationships among in vitro mutagenicity assays: quantitative vs. qualitative test results

Environ Mol Mutagen. 1995;26(2):155-62. doi: 10.1002/em.2850260209.

Abstract

In previous investigations, we studied the relationships between the profiles of the qualitative responses of in vitro short-term tests (mutation in Salmonella typhimurium, chromosomal aberrations in CHO cells, sister chromatid exchanges in CHO cells, and mutation in mouse lymphoma cells) and common sets of chemicals. In this paper, we address the study of the quantitative responses (potency). We show that two analyses point to similar patterns of relationships: the mutation in mouse lymphoma cells assay is most similar to the CHO sister chromatid exchange assay, and the Salmonella assay is most similar to the CHO chromosomal aberrations assay.

Publication types

  • Comparative Study

MeSH terms

  • Analysis of Variance
  • Animals
  • CHO Cells / cytology
  • Chromosome Aberrations / genetics
  • Cluster Analysis
  • Cricetinae
  • Lymphoma / pathology
  • Mice
  • Mutagenicity Tests* / standards
  • Mutagens / toxicity
  • Mutation / genetics*
  • Salmonella typhimurium / genetics
  • Sister Chromatid Exchange / genetics
  • Species Specificity
  • Structure-Activity Relationship
  • Tumor Cells, Cultured

Substances

  • Mutagens