Abstract
We recently cloned human cDNA representing several mRNA isoforms of human TCF11, a transcription factor of the basic-region, leucine-zipper (bZIP) family located on chromosome 17q22 as well as a genomic clone of this gene. We have now determined the complete genomic organization of the TCF11 gene, which consists of 9 exons distributed over 15 kb of genomic DNA. Pulsed-field gel electrophoresis was used to construct a physical map around TCF11, to characterize a 450-kb YAC clone that contains the gene, and to link TCF11 physically to BTR, a marker on chromosome 17.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Blotting, Southern
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Caenorhabditis / genetics
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Caenorhabditis elegans Proteins*
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Chromosome Mapping
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DNA Probes
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DNA, Complementary / chemistry
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DNA-Binding Proteins*
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Exons
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Helminth Proteins / genetics
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Humans
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Mice
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Molecular Sequence Data
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NF-E2-Related Factor 1
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Sequence Homology
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Transcription Factors / genetics*
Substances
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Caenorhabditis elegans Proteins
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DNA Probes
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DNA, Complementary
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DNA-Binding Proteins
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Helminth Proteins
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NF-E2-Related Factor 1
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NFE2L1 protein, human
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Transcription Factors
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skn-1 protein, C elegans
Associated data
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GENBANK/X84060
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GENBANK/X84061
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GENBANK/X84062
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GENBANK/X84063
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GENBANK/X84064
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GENBANK/X84065
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GENBANK/X84066