Abstract
CD38 is an ectoenzyme that utilizes NAD+ and is expressed by many cells of hematopoietic origin. Antibodies to CD38 potentiate many biological activities on lymphocytes, including induction of murine B-cell proliferation. In this article, Frances Lund and colleagues summarize information concerning the expression, enzymatic activity and signal transduction pathway utilized by murine CD38.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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ADP-ribosyl Cyclase
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ADP-ribosyl Cyclase 1
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Animals
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Antigens, CD*
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Antigens, Differentiation / immunology*
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B-Lymphocytes / enzymology
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B-Lymphocytes / immunology*
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Lymphocyte Activation
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Membrane Glycoproteins
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Mice
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N-Glycosyl Hydrolases / immunology*
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Signal Transduction
Substances
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Antigens, CD
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Antigens, Differentiation
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Membrane Glycoproteins
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N-Glycosyl Hydrolases
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ADP-ribosyl Cyclase
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Cd38 protein, mouse
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ADP-ribosyl Cyclase 1