Abstract
The effect of vitamin supplements on bone metabolism indices in patients with osteoporosis has received scant attention in the literature. Over a 2-week period, vitamin supplements of K and K+D were given to 20 post-menopausal osteoporotic women with previous Colles fractures. Osteoporosis was confirmed by bone mass measurements that demonstrated that broadband ultrasound attenuation (os calcis) was almost as discriminatory as dual energy X-ray absorptiometry (spine and hip) in Colles fracture patients compared with matched controls. Vitamin K corrected the carboxylation defect in osteocalcin and while less marked 4 weeks later, the improvement was still detectable. The result after K+D was similar. The level of carboxylation became the same as in premenopausal women. Total osteocalcin level (bound) osteocalcin. While there was vitamin K correctable undercarboxylation of osteocalcin, simultaneously there was no evidence of undercarboxylation of prothrombin.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Absorptiometry, Photon
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Adult
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Aged
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Biomarkers*
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Bone Density / drug effects
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Colles' Fracture / diagnostic imaging
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Colles' Fracture / physiopathology
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Cross-Over Studies
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Female
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Femur / diagnostic imaging
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Femur / physiology
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Humans
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Middle Aged
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Osteocalcin / blood
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Osteocalcin / chemistry
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Osteocalcin / metabolism*
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Osteoporosis, Postmenopausal / diagnostic imaging
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Osteoporosis, Postmenopausal / drug therapy*
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Osteoporosis, Postmenopausal / metabolism
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Premenopause / blood
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Protein Precursors / metabolism
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Prothrombin / chemistry
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Prothrombin / metabolism
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ROC Curve
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Single-Blind Method
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Spinal Canal / diagnostic imaging
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Spinal Canal / physiology
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Ultrasonography
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Vitamin D / administration & dosage
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Vitamin D / pharmacology
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Vitamin D / therapeutic use*
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Vitamin K / administration & dosage
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Vitamin K / pharmacology
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Vitamin K / therapeutic use*
Substances
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Biomarkers
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Protein Precursors
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Osteocalcin
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Vitamin K
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Vitamin D
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acarboxyprothrombin
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Prothrombin