Plasma levels of IL-1, TNF alpha, IL-6, IL-8, G-CSF, and IL1-RA during febrile neutropenia: results of a prospective study in patients undergoing chemotherapy for acute myelogenous leukemia

Ann Hematol. 1995 Oct;71(4):161-8. doi: 10.1007/BF01910312.

Abstract

Plasma levels of IL-1, IL-6, IL-8, IL1-RA, TNF alpha, and G-CSF were prospectively studied during 23 chemotherapy cycles of 20 patients suffering from acute myelogenous leukemia. Increased plasma levels of IL-6, IL-8, and G-CSF were observed in patients with febrile neutropenia and/or major infection. Plasma levels of IL-6, IL-1, TNF alpha and IL-1-RA measured 1 day before and 1 day after the onset of febrile episodes did not accurately predict the development of major infection. In contrast, IL-8 plasma levels were significantly higher in those patients who subsequently developed major infection. The question whether IL-8 plasma levels identify high risk or low risk patients with sufficient specificity and sensitivity has to be answered in large scale clinical trials.

MeSH terms

  • Adolescent
  • Adult
  • Animals
  • Antimetabolites, Antineoplastic / administration & dosage
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Cytarabine / administration & dosage
  • Cytokines / blood*
  • Dacarbazine / administration & dosage
  • Female
  • Fever
  • Granulocyte Colony-Stimulating Factor / blood
  • Humans
  • Interleukin 1 Receptor Antagonist Protein
  • Interleukin-1 / antagonists & inhibitors
  • Interleukin-2 / blood
  • Interleukin-6 / blood
  • Interleukin-8 / blood
  • Leukemia, Myeloid, Acute / blood
  • Leukemia, Myeloid, Acute / complications
  • Leukemia, Myeloid, Acute / drug therapy*
  • Male
  • Middle Aged
  • Mitoxantrone / administration & dosage
  • Neutropenia / blood*
  • Neutropenia / etiology
  • Nimustine / administration & dosage
  • Prospective Studies
  • Sialoglycoproteins / blood
  • Tumor Necrosis Factor-alpha / analysis
  • Vincristine / administration & dosage

Substances

  • Antimetabolites, Antineoplastic
  • Cytokines
  • IL1RN protein, human
  • Interleukin 1 Receptor Antagonist Protein
  • Interleukin-1
  • Interleukin-2
  • Interleukin-6
  • Interleukin-8
  • Sialoglycoproteins
  • Tumor Necrosis Factor-alpha
  • Cytarabine
  • Nimustine
  • Granulocyte Colony-Stimulating Factor
  • Vincristine
  • Dacarbazine
  • Mitoxantrone

Supplementary concepts

  • DAV protocol
  • NOAC protocol