Non-X histiocytoma, similar to fibrous histiocytoma, in an infant

Pathol Int. 1995 Jun;45(6):452-6. doi: 10.1111/j.1440-1827.1995.tb03484.x.

Abstract

A case is presented of a female infant with an atypical histiocytoma. A gradually enlarging brown lesion was noted on the left side of the chest at the age of 2 weeks. Microscopic study of a biopsy revealed an ill-defined infiltration of spindle cells with indented nuclei. The tumor cells were positive for CD14, HLA-DR, lysozyme, alpha-1-antitrypsin and alpha-1-antichymotrypsin, and negative for CD1, CD3, CD8, CD10, CD19, CD68 and S-100 by immunohistochemistry. Electron microscopy demonstrated no distinct Birbeck's granules, but aberrant granules were seen in a small number of cells. At 7 months of age, a nodule with similar histologic features was noted in the nuchal region, but was incompletely resected. The patient remains recurrence-free at 36 months of age. This case is thought to be a benign form of non-X histiocytoma.

Publication types

  • Case Reports

MeSH terms

  • Diagnosis, Differential
  • Female
  • Histiocytoma, Benign Fibrous / chemistry
  • Histiocytoma, Benign Fibrous / pathology*
  • Histiocytoma, Benign Fibrous / ultrastructure
  • Histiocytosis, Langerhans-Cell / metabolism
  • Histiocytosis, Langerhans-Cell / pathology*
  • Humans
  • Immunohistochemistry
  • Infant
  • Neoplasm Recurrence, Local