Immunophilins and the nervous system

Nat Med. 1995 Jan;1(1):32-7. doi: 10.1038/nm0195-32.

Abstract

The search for immunosuppressant drugs to increase the success of organ transplantation led to the discovery of the immunophilins, proteins that interface with a range of signal transduction systems inside cells, especially in the nervous and immune systems. Here we review how these interesting molecules work and consider their therapeutic potential.

Publication types

  • Review

MeSH terms

  • Amino Acid Isomerases / physiology*
  • Animals
  • Calcineurin
  • Calmodulin-Binding Proteins / physiology
  • Carrier Proteins / physiology*
  • DNA-Binding Proteins / physiology*
  • Heat-Shock Proteins / physiology*
  • Humans
  • Immunosuppressive Agents / pharmacology*
  • Nervous System Physiological Phenomena*
  • Peptidylprolyl Isomerase
  • Phosphoprotein Phosphatases / physiology
  • Polyenes / pharmacology
  • Signal Transduction
  • Sirolimus
  • Tacrolimus Binding Proteins

Substances

  • Calmodulin-Binding Proteins
  • Carrier Proteins
  • DNA-Binding Proteins
  • Heat-Shock Proteins
  • Immunosuppressive Agents
  • Polyenes
  • Calcineurin
  • Phosphoprotein Phosphatases
  • Amino Acid Isomerases
  • Tacrolimus Binding Proteins
  • Peptidylprolyl Isomerase
  • Sirolimus