The full benefits of thrombolytic therapy can be realized if and only if treatment is delivered as quickly as possible. Streamlining the triage system will not only increase the numbers of patients treated with thrombolytic therapy, it will ultimately reduce mortality and morbidity rates from acute myocardial infarction by limiting loss of heart muscle. Reducing the time to treatment, however, is a daunting task given that both patient and hospital delays contribute to the underutilization or inefficient use of thrombolytic therapy. In particular, patient delays can be difficult to attenuate, given that human behavior is complex and that designing interventions to change behavior is not only challenging but expensive. Results from the MITI registry show that the emergency medical system is the linchpin of an efficient triage system in that it is associated with reduced patient delays as well as reduced treatment delays. Clearly, patients with chest pain need to be aware of the need to take prompt action by calling 911. On the other hand, decisions to use these systems to acquire electrocardiograms or deliver thrombolytic treatment will be faced by increasing numbers of administrators and policy makers in the years to come. Without adequate community support to maintain and improve these systems, the full benefits of thrombolytic therapy cannot be attained.