Rebamipide, novel prostaglandin-inducer accelerates healing and reduces relapse of acetic acid-induced rat gastric ulcer. Comparison with cimetidine

Dig Dis Sci. 1995 Nov;40(11):2469-72. doi: 10.1007/BF02063257.

Abstract

This study was done to elucidate whether rebamipide during the initial period of acetic acid-induced gastric ulcer affected healing and future ulcer relapse. The cumulative healing rate was higher in rats given rebamipide alone or those given rebamipide and cimetidine during and after administration, but not in rats given cimetidine alone, compared to control rats. Cumulative relapse rate was significantly lower in rats initially given rebamipide alone or those given rebamipide and cimetidine than in rats initially given cimetidine alone. These results suggest that rebamipide is beneficial for obtaining a better quality of ulcer healing and reduction of future ulcer relapse.

Publication types

  • Comparative Study

MeSH terms

  • Acetates
  • Acetic Acid
  • Alanine / administration & dosage
  • Alanine / analogs & derivatives*
  • Alanine / therapeutic use
  • Animals
  • Anti-Ulcer Agents / administration & dosage
  • Anti-Ulcer Agents / therapeutic use*
  • Cimetidine / administration & dosage
  • Cimetidine / therapeutic use*
  • Drug Therapy, Combination
  • Male
  • Prostaglandins / biosynthesis
  • Quinolones / administration & dosage
  • Quinolones / therapeutic use*
  • Rats
  • Rats, Wistar
  • Recurrence
  • Stomach Ulcer / chemically induced
  • Stomach Ulcer / drug therapy*
  • Stomach Ulcer / prevention & control
  • Wound Healing / drug effects

Substances

  • Acetates
  • Anti-Ulcer Agents
  • Prostaglandins
  • Quinolones
  • Cimetidine
  • rebamipide
  • Alanine
  • Acetic Acid