Abstract
The Drosophila transient receptor potential (trp) gene and its homologue, trpl, have been suggested to mediate calcium entry during the insect's phototransduction process. We isolated a human cDNA, human trp-1 (Htrp-1), encoding a polypeptide of 793 amino acids that is 37% identical (62% similar) to Drosophila trp and trpl. Northern analysis showed that the Htrp-1 transcript is approximately 5.5 kb and expressed in most human tissues, with higher amounts in ovary, testis, heart, and brain. Isolation of Htrp-1 suggests that a trp-type protein is present in mammals and should provide a useful tool in studying calcium-depletion induced calcium influx processes.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Biological Evolution
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Blotting, Northern
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Calcium / metabolism
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Calcium Channels / chemistry
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Calcium Channels / genetics*
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Calmodulin-Binding Proteins / chemistry
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Calmodulin-Binding Proteins / genetics
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Cloning, Molecular*
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DNA, Complementary
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Drosophila / genetics*
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Drosophila Proteins*
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Gene Expression
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Genes, Insect
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Humans
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Inositol 1,4,5-Trisphosphate / metabolism
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Insect Hormones / chemistry
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Insect Hormones / genetics*
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Insect Proteins*
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Membrane Proteins / chemistry
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Membrane Proteins / genetics
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Molecular Sequence Data
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Sequence Alignment
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Sequence Homology, Amino Acid
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TRPC Cation Channels
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Transient Receptor Potential Channels
Substances
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Calcium Channels
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Calmodulin-Binding Proteins
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DNA, Complementary
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Drosophila Proteins
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Insect Hormones
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Insect Proteins
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Membrane Proteins
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TRPC Cation Channels
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Transient Receptor Potential Channels
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transient receptor potential cation channel, subfamily C, member 1
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trp protein, Drosophila
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trpl protein, Drosophila
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Inositol 1,4,5-Trisphosphate
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Calcium