Abstract
The PACAP-R gene, encoding the mouse pituitary adenylate cyclase-activating polypeptide receptor (PACAP-R), has been isolated and its structural organization has been determined. PACAP-R spans more than 50 kb and is divided into 18 exons. PACAP-R contains two alternative exons encoding the putative third intracellular loop, as found in the rat PACAP-R. The proximal promoter region is highly G+C rich and lacks an apparent TATA box, but contains a CCAAT box and two potential Sp1-binding sites.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Base Composition
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Base Sequence
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Binding Sites
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DNA / chemistry
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DNA / genetics
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Exons
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Genes, Regulator
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Mice / genetics*
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Molecular Sequence Data
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Molecular Weight
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Promoter Regions, Genetic
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Rats
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Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide
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Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I
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Receptors, Pituitary Hormone / biosynthesis
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Receptors, Pituitary Hormone / genetics*
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Restriction Mapping
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Sp1 Transcription Factor / metabolism
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TATA Box
Substances
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Adcyap1r1 protein, mouse
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Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide
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Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I
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Receptors, Pituitary Hormone
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Sp1 Transcription Factor
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DNA