Abstract
The presence of atypical moles (AM) is considered to be a marker for an increased risk of developing cutaneous malignant melanoma (MM). The extent to which individuals with the atypical-mole syndrome (AMS) are at risk for developing MM is unknown. We present a review of the world literature and of our experience at New York University. We conclude that the presence of AMS in Caucasians significantly increases the risk of developing MM, regardless of geographic location. A further increase in MM risk is noted if there is a personal and/or family history of MM.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Case-Control Studies
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Dysplastic Nevus Syndrome / epidemiology*
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Dysplastic Nevus Syndrome / genetics
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Follow-Up Studies
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Genetic Predisposition to Disease
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Global Health
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Humans
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Melanoma / epidemiology*
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Melanoma / genetics
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Melanoma / prevention & control
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New York City / epidemiology
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Prospective Studies
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Retrospective Studies
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Risk
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Risk Factors
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Skin Neoplasms / epidemiology*
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Skin Neoplasms / genetics
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Skin Neoplasms / prevention & control
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White People / genetics