Abstract
Based on clinical studies, a negative association between Helicobacter pylori and autoimmune corpus gastritis is described. In the present investigation of an unselected population of 1461 adults we can state, however, that there exists a relationship between H. pylori infection and the development of gastric corpus autoimmunity. As confirmation for the gastric autoantibody development through molecular mimicry, a high homology (72% in 25 amino acid overlap) between the beta subunit of H. pylori urease and that of H + K + ATPase, the gastric parietal cell autoantigen, was revealed.
MeSH terms
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Adolescent
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Adult
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Aged
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Amino Acid Sequence
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Animals
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Antigens, Bacterial / genetics
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Autoantibodies / blood
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Autoantigens / genetics
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Autoimmune Diseases / microbiology*
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Cohort Studies
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Estonia
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Female
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Gastritis / immunology
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Gastritis / microbiology*
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H(+)-K(+)-Exchanging ATPase / genetics
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Helicobacter Infections / immunology*
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Humans
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Immunoglobulin G / blood
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Male
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Mice
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Middle Aged
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Molecular Sequence Data
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Parietal Cells, Gastric / enzymology
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Parietal Cells, Gastric / immunology
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Rats
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Sequence Homology, Amino Acid
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Urease / genetics
Substances
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Antigens, Bacterial
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Autoantibodies
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Autoantigens
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Immunoglobulin G
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Urease
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H(+)-K(+)-Exchanging ATPase