Abstract
In order to confirm the proposed structures of two metabolites 3 and 4 of the gastroprokinetic agent mosapride [4-amino-5-chloro-2-ethoxy-N-([4-(4-fluorobenzyl)-2-morpholinyl] methyl)benzamide, 2], the compounds were synthesized and their biological activity was examined. The structures of the metabolites were confirmed by means of comparison with the synthetic compounds. The serotonin 5-HT4 receptor agonistic activities of the metabolites were found to be less than that of mosapride.
MeSH terms
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Animals
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Benzamides / chemical synthesis*
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Benzamides / chemistry
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Benzamides / pharmacology
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Gastrointestinal Agents / chemical synthesis*
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Gastrointestinal Agents / chemistry
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Gastrointestinal Agents / pharmacology
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Guinea Pigs
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Ileum / drug effects
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Ileum / physiology
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In Vitro Techniques
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Male
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Morpholines / chemical synthesis*
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Morpholines / chemistry
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Morpholines / pharmacology
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Serotonin Receptor Agonists / pharmacology
Substances
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Benzamides
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Gastrointestinal Agents
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Morpholines
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Serotonin Receptor Agonists
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mosapride