Chromosomal localization of the gene encoding the human DNA helicase RECQL and its mouse homologue

Genomics. 1995 Apr 10;26(3):595-8. doi: 10.1016/0888-7543(95)80181-k.

Abstract

We have determined the chromosomal location of the human and mouse genes encoding the RECQL protein, a putative DNA helicase homologous to the bacterial DNA helicase, RecQ. RECQL was localized to human chromosome 12 by analysis of human-rodent somatic cell hybrid DNA; fine mapping of RECQL by fluorescence in situ hybridization revealed its chromosomal location to be 12p11-p12. The corresponding mouse gene, Recql, was mapped to the telomeric end of mouse chromosome 6 by analysis of DNA from an interspecific cross.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenosine Triphosphatases / genetics*
  • Animals
  • Chromosome Mapping*
  • Chromosomes, Human, Pair 12*
  • DNA Helicases / genetics*
  • Genetic Linkage
  • Humans
  • In Situ Hybridization, Fluorescence
  • Mice
  • Mice, Inbred C3H
  • RecQ Helicases

Substances

  • Adenosine Triphosphatases
  • RECQL4 protein, human
  • DNA Helicases
  • RecQ Helicases