Glycinergic inhibition of spontaneously active guinea-pig medial vestibular nucleus neurons in vitro

Neurosci Lett. 1995 Mar 31;188(3):155-8. doi: 10.1016/0304-3940(95)11418-v.

Abstract

Effects of glycine on the spontaneous activity of medial vestibular nucleus (MVN) neurons recorded extracellularly from guinea-pig brainstem slices were investigated. Glycine produced a dose-dependent decrease in the resting discharge rate of all MVN neurons tested, with a mean EC50 of 3.9 x 10(-4) M. The inhibitory effect of glycine was reversibly blocked by strychnine and persisted in a low calcium/high magnesium-containing saline solution. These findings suggest the existence of a direct strychnine-sensitive inhibitory effect of glycine on guinea-pig MVN neurons.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Calcium / pharmacology
  • Electrophysiology
  • Glycine / pharmacology*
  • Guinea Pigs
  • In Vitro Techniques
  • Magnesium / pharmacology
  • Male
  • Neural Inhibition / physiology*
  • Neurons / drug effects
  • Presynaptic Terminals / drug effects
  • Sensitivity and Specificity
  • Strychnine / pharmacology
  • Synaptic Transmission / drug effects
  • Vestibular Nuclei / cytology
  • Vestibular Nuclei / physiology*

Substances

  • Strychnine
  • Magnesium
  • Calcium
  • Glycine